Treatments to prevent travel sickness: a quick look

Travel sickness, an uncomfortable and disruptive condition made up of nausea and vomiting, can occur during car, train, boat and even airplane travel. Fortunately, there are treatments available to help travelers cope with travel sickness. By understanding the various treatments and how they work, travelers can make an informed decision on which treatment is best for their particular journey.

The most effective and commonly used treatment for travel sickness is over-the-counter drugs, like Dramamine and Bonine. These types of drugs work by targeting the parts of the brain that control nausea and vomiting, preventing those uncomfortable symptoms from occurring. Over-the-counter drugs typically come in suppositories, pills, or liquids and should be taken one hour before the journey. Side effects may include drowsiness, headaches, and mild stomach upset.

Another option is the use of natural remedies. Natural remedies such as ginger and peppermint can help reduce nausea and other symptoms associated with travel sickness, though they may take multiple days to take full effect. Choose one or two of the remedies, such as ginger tea or eating candied ginger. For some, drinking water is also beneficial. Note that natural remedies may interact with other medications so it is best to consult with a doctor before taking any herbal supplements or treatments.

Finally, many travelers opt to use techniques like deep breathing, distraction, and focusing on the horizon, to help reduce symptoms associated with travel sickness. Sitting facing forward with eyes focused on a distant object, drinking tiny sips of water, and avoiding reading may also help. Acupressure, which involves applying pressure to certain points on the body, as well as hypnosis may be effective for some cases, though their efficacy is still under study.

In conclusion, there are several treatments available to help travelers reduce their symptoms of travel sickness. Over-the-counter medications are probably the most effective and widely used, but for those seeking more natural solutions, natural remedies and techniques may be beneficial. Be sure to speak with a doctor before embarking on any journey to make sure the best treatment is chosen.

In this short blog, Dr Robert Walton looks at the evidence on treatments to prevent travel sickness (motion sickness).

Take-home points

Take-home points: Effective preventative treatments are available for travel sickness The choice is between hyoscine and older ‘first generation’ antihistamines New Cochrane evidence shows that some antihistamines are likely to reduce the risk of travel sickness in adults. They may cause drowsiness

The new evidence on antihistamines comes from the Cochrane Review Antihistamines for motion sickness (published in October 2022) and is relevant to adults.

Travel sickness (motion sickness) is a common problem, and many people experience nausea for example on boats, planes or in the car. Lots of treatments which aim to prevent travel sickness are available to buy in UK pharmacies, including medicines. Here is the evidence on these medicines and some things you may want to think about when making your choices.

Making a choice? Think BRAIN!

It can be helpful to think BRAIN: What are the Benefits, Risks, Alternatives, what do I want and what if I do Nothing? These can be good questions to talk about with a health professional when making a health decision.

Medicines to prevent travel sickness

The choice is between hyoscine (or scopolamine as it is sometimes called) and antihistamines such as cinnarizine.

Most of the Cochrane evidence is focused on hyoscine which is probably better than placebo (dummy treatment) at preventing travel sickness.  It comes from the Cochrane Review Scopolamine (hyoscine) for preventing and treating motion sickness (published June 2011).

The new Cochrane evidence about antihistamines, from the Cochrane Review Antihistamines for motion sickness (published October 2022) finds that they are likely to reduce the risk of travel sickness in adults who tend to get it, compared with taking a placebo.

It’s worth bearing in mind that there is evidence to support using older or ‘first generation’ antihistamines but none for the newer medicines such as loratadine and cetirizine which are more commonly used now for hay fever now.  These newer antihistamines are not used to prevent or treat motion sickness and are unlikely to be effective.

There are few studies comparing the two types of medicines.  There is little information about whether either are useful for treating motion sickness after it has started so prevention may be better than cure.

What are the risks?

Hyoscine and antihistamines both work in the same way for preventing travel sickness and they also share the same side effects which include drowsiness in some people.

What are the other options?

Many other options are available but there is no Cochrane evidence about their potential benefits and harms.

What do I want?

What matters (most) to you, and past experiences of a problem – and of treatments, is important when making treatment choices. If you usually get travel sickness and want to prevent it then there are medicines that can help and are backed up by Cochrane evidence. But it may be important to you to avoid the risk of side effects (such as drowsiness, if you have to drive for example). You could discuss your options and experience of treatments with a pharmacist.

What if I do nothing?

Travel sickness is usually not usually a big problem although some people can be quite severely affected.  If you have had it once in a particular situation then you are likely to get it again.

Find out more

NHS pages on motion sickness

The Cochrane Reviews:

Karrim N, Byrne R, Magula N, Saman Y. Antihistamines for motion sickness. Cochrane Database of Systematic Reviews 2022, Issue 10. Art. No.: CD012715. DOI: 10.1002/14651858.CD012715.pub2.

Spinks A, Wasiak J. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database of Systematic Reviews 2011, Issue 6. Art. No.: CD002851. DOI: 10.1002/14651858.CD002851.pub4.

Why you can trust this information

Join in the conversation on Twitter with @CochraneUK @rtwalton123 or leave a comment on the blog. 

Please note, we cannot give specific medical advice and do not publish comments that link to individual pages requesting donations or to commercial sites, or appear to endorse commercial products. We welcome diverse views and encourage discussion but we ask that comments are respectful and reserve the right to not publish any we consider offensive. Cochrane UK does not fact-check – or endorse – readers’ comments, including any treatments mentioned.

Robert Walton has nothing to disclose.



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