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How Huntington’s disease affects different neurons

Data from the human Grade 1 HD patient indicate the loss of compartmental identities as a conserved signature of HD. Credit: Nature Communications (2023). DOI: 10.1038/s41467-022-35752-x In patients with Huntington’s disease, neurons in a...

Researchers find hybrid immunity is the best protection against COVID-19

Protection against omicron variant conferred by the primary series vaccine, first booster vaccine, previous infection, and hybrid immunity compared to immune-naive individuals over time. The shaded areas denote 95% CIs. Vaccine effectiveness data were...

Discovery of cancer-associated fibroblast origin gives new direction for pancreatic cancer research

Epithelium and bone marrow minimally contribute to pancreatic cancer associated fibroblasts. a Schematic of the KPFG mouse model. b–d Co-immunostaining in the KPFG pancreas and quantification of cells that are either single positive or...

Analysis of seemingly recovered COVID-19 patients indicates that SARS-CoV-2 infection can persist significantly longer than suggested by PCR-negative tests

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can persistently progress into a deadly condition even after clinical resolution of the acute infection suggested by polymerase chain reaction (PCR)...

An unexpected approach to treating bronchial asthma: Modify dietary fats

Credit: Point Fr/Shutterstock Bronchial asthma, a chronic inflammatory disease of the airways that is reversible in certain cases, usually presents with cough, difficulty of breathing, and wheezing. Although most people can successfully control asthma...

Antiviral compound could be broadly efficient in the treatment of SARS-CoV-2

Grphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01243 A new study led by Gonçalo Bernardes, group leader at the Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) and Professor at the University...

Overdose deaths involving buprenorphine did not proportionally increase with new prescribing flexibilities: Study

Credit: Pixabay/CC0 Public Domain The proportion of opioid overdose deaths involving buprenorphine, a medication used to treat opioid use disorder, did not increase in the months after prescribing flexibilities were put in place during...

Getting kids back to school sooner after a concussion can mean a faster recovery

Credit: Unsplash/CC0 Public Domain Contrary to popular belief, rest from school may not always be the best after a concussion, a new study published in JAMA Network Open finds. In fact, an early return...

Getting under your skin for better health with interstitial fluid testing

Methods for the extraction of ISF. a, Wick extraction inserts an absorbent wicking material into the dermis and relies on capillary action to saturate the wick with whole ISF or analytes for subsequent analysis....

Examining COVID-19’s long-term effects on the innate immune system

Marie Larsson, Professor of virology at Linköping University. Credit: Cecilia Säfström/Linköping University The more severe the COVID-19 infection, the slower the recovery of immune cells, such as the dendritic cells, which are necessary for...

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